流通池法测定药物溶出度的应用进展

赵洁,,,易红,,刘晓谦*,,,李东影,,,徐雪林,,,王智民*,

中国药学杂志 ›› 2014, Vol. 49 ›› Issue (17) : 1486-1490.

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中国药学杂志 ›› 2014, Vol. 49 ›› Issue (17) : 1486-1490. DOI: 10.11669/cpj.2014.17.003
综 述

流通池法测定药物溶出度的应用进展

  • 赵洁1,2,3,易红2,3,刘晓谦2*,3,5,李东影1,2,3,徐雪林2,3,4,王智民2*,3
作者信息 +

Progress in Application of Flow-through Cell Method for Determination of Drug Dissolution

  • ZHAO Jie1,2,3, YI Hong2,3, LIU Xiao-qian2*,3,5,LI Dong-ying1,2,3, XU Xue-lin2,3,4, WANG Zhi-min2*,3
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文章历史 +

摘要

目的 综述流通池法测定药物溶出度的研究进展和应用情况。方法 以国内外发表的关于流通池法测定药物溶出度的研究论文为基础,对该方法的发展历程、应用原理、该方法如何模拟体内环境、如何满足日益涌现的新型制剂评价要求等关键问题进行探讨。结果与结论 流通池法作为一种新型的溶出度检查方法较传统方法更能满足当代涌现出的大量新剂型以及对于溶出度测定方法体内外相关性的要求,在制剂方面的研究和质量控制方面有着非常广阔的前景。

Abstract

OBJECTIVE To indroduce the research progress and application of an innovative dissolution test method-flow-through cell method (FTC). METHODS The development process, application of the principle, key problems and utilization examples of FTC were reviewed in this article based on the published papers worldwide. RESUTLS AND CONCLUSION As an innovative dissolution test method, flow-through cell method (FTC) has many obvious advantages compared with the conventional paddle/basket method. It overcomes some shortcomings of traditional dissolution methods, especially in the determination of controlled-release formulations and some new preparations.

关键词

流通池法 / 溶出度 / 新技术

Key words

flow-through cell method / dissolution / new technology

引用本文

导出引用
赵洁,,,易红,,刘晓谦*,,,李东影,,,徐雪林,,,王智民*,. 流通池法测定药物溶出度的应用进展[J]. 中国药学杂志, 2014, 49(17): 1486-1490 https://doi.org/10.11669/cpj.2014.17.003
ZHAO Jie,,, YI Hong,, LIU Xiao-qian*,,,LI Dong-ying,,, XU Xue-lin,,, WANG Zhi-min*,. Progress in Application of Flow-through Cell Method for Determination of Drug Dissolution[J]. Chinese Pharmaceutical Journal, 2014, 49(17): 1486-1490 https://doi.org/10.11669/cpj.2014.17.003
中图分类号: R917   

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基金

973计划项目(2012CB724001);国家自然科学基金资助项目(81274079);中国中医科学院客座研究员联合创新研究项目(ZZ070837);国家 “重大新药创制”科技重大专项(2012ZX09103201-009,2012ZX09103201-027)
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